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KMID : 0613820020120020144
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Journal of Life Science
2002 Volume.12 No. 2 p.144 ~ p.150
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Antioxidant Activities of Chrysanthemum coronarium L. Fractions on the Liposomal Phospholipid Membrane
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Noh Ok-Jeong
Bae Song-Ja
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Abstract
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This experiment was designed to investigate the antioxidant effects of Chrysanthemum coronarium L. (CC) fractions on the liposomal phospholipid membranes. The sample CC was extracted and fractionated into five different types, methanol (CCMM), hexane (CCMH), ethylacetate (CCMEA), butanol (CCMB), and aqueous (CCMA) fractions. The antioxidant activities of CC fractions in oxidized dilinoleoylphosphatidylcholine (DLPC) liposomes were examined by spectrophotometry measuring conjugated dienes. The oxidation indices of five CC fractions exhibited weaker antioxidant activities than that of BHT in oxidized DLPC liposomes, however, showing much similar antioxidant activities of α-tocopherol in the oxidized DLPC liposomes, which is known as a potent antioxidant. Among CC fractions, CCMM and CCMA in oxidized DLPC liposomes showed rather effective than α-tocopherol after 2 h. These results strongly indicate that bioactive substances in CC fractions have a kind of function as potent antioxidants against biomembrane oxidation.
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KEYWORD
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Chrysanthemum coronarium L., antioxidant activity, DLPC, liposome
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